T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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Mast cells are immune cells that migrate from blood into connective tissue. They engage in inflammatory responses by releasing molecules that dilate blood vessels and recruit other cells. They play a key role in allergic reactions.
A mast cell contains abundant, large granules that contain inflammatory substances (histamine and heparin). Stimulation by an antigen results in degraunulation.