T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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Mast cells are immune cells that can migrate from blood into connective tissue. They engage in inflammatory responses by releasing molecules that dilate blood vessels and recruit other cells. They play a key role in allergic reactions.
A mast cell contains abundant, large granules that contain inflammatory substances (histamine and heparan). This one is in the connective tissue enclosed by several simple squamous epithelia.
Cell Types:
Mast cell (green) - degranulates upon stimulation by an antigen.
Granules (purple) - heterogeneous in size, contents, and function.