T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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Ultrastructue of the renal filtration barrier (TEM). Fluid passes through the fenestrations of capillaries, the basement membrane, and the thin slit diaphragms between pedicils of the podocytes.
Capillary (green) - endothelial cells with many pores (or fenestrations) lacking diaphragms
The filtrate is collected in the urinary space of Bowman's capsule.
Mesangial cells (cyan) and matrix (yellow) between capillary loops that help form the structure of the glomerulus and have a phagocytic role in maintaining the basement membrane.