T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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Cardiac muscle is striated, involuntary muscle found in the heart wall. Cardiac muscle cells (or cardiomyocytes) contain the same contractile filaments as in skeletal muscle. Unlike skeletal muscle, cardiac muscle cells are smaller with a centrally located nucleus.
Longitudinal Section - cardiac muscle cells are intermediate in size compared to skeletal muscle and smooth muscle.
Branched Cells - cells are joined end-to-end and are often branched.
Nuclei - cells have a single or occasionally two centrally located nuclei.
Intercalated Discs - cells are joined together by specialized junctions called intercalated discs. They are usually unstained, but occasionally appear as thin, dark line dividing adjacent cells. The intercalated discs are perpendicular to the direction of muscle fibers. They are best seen when stained with phospho-tungstic acid (MH 056 Muscle Types).
Lipofuscin Pigment - residue of lysosomal digestion that accumulates as yellow-brown granules near the nucleus of some cells.