MH 160a Ovary

MICROSCOPE SLIDE

SLIDE NAME

MH 160a Ovary

TISSUE

Ovary (Adult)

STAIN

Hematoxylin & Eosin

IMAGE SIZE

32,980 x 14,496 pixels
1.8 GB

FILE SIZE

70 MB

MAGNIFICATION

40x

PIXEL SIZE

0.3171 µm

SOURCE

Medical Histology Collection

CONTACT

Questions or comments should be sent to
tcbrelje@gmail.com

This web site is owned and operated by:

T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Version 4.2

© 2005-2019.
T. Clark Brelje and Robert L. Sorenson.
All rights reserved.

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MH 160a Ovary

Ovary

Ovaries produce female gametes (oocytes) and steroid hormones (estrogen and progesterone).

Capsule - covers the outer surface.

Germinal Epithelium - the surface is covered by a simple cuboidal epithelium. (Missing from most of this specimen.)
Tunica Albuginea - layer of dense irregular connective tissue that supports the epithelium.

Cortex - outer region that is the site of oocyte development. This specimen is mostly cortex.

Ovarian Follicles - oocytes surrounded by one or more layers of cells.

Primordial Follicles - oocytes arrested in development. They are most abundant type of follicle and located in the outer cortex.

Primary Oocyte - large (25 to 30 µm), round to oval cells with a vesicular nucleus.
Follicular Cells - single layer of flattened cells that surround each oocyte.

Primary Follicles - develop from primordial follicles.

Primary Oocyte - large (25 to 30 µm), round to oval cells with a vesicular nucleus.
Stratum Granulosum - one or more layers of cuboidal-shaped granulosa cells (which develop from follicular cells).

Ovary

Secondary (Antral) Follicles - characterized by the formation an antrum (a fluid-filled space) containing an oocyte.

Oocyte - large (50 to 100 µm), round to oval cells with a vesicular nucleus.
Zona Pellucida - layer of glycoproteins between the oocyte and granulosa cells (eosinophilic).
Granulosa Cells - continue to proliferate and form multiple structures:

Corona Radiata - several layers of cells immediately surrounding the oocyte.
Cumulus Oophorus - group of cells anchored to the follicle wall that contains the oocyte.
Stratum Granulosum - multiple layers of cells that form the follicle wall that surrounds the antrum. (It is avascular.)

Theca Folliculi - stromal cells around the follicle develop into a sheath of highly vascularized connective tissue.

Theca Interna - inner cellular layer with many blood vessels.

Secrete androgens that are converted to estrogen by granulosa cells.

Theca Externa - outer more fibrous layer.

Ovary

Mature (or Graafian) Follicles - usually only one follicle will continue to grow each cycle to form a very large, mature follicle (25 mm or more in diameter).

Oocyte - not visible in most sections because of the large size of mature follicles.
Stratum Granulosum - becomes thinner as the follicle continues to grow in size. (It is avascular.).
Theca Folliculi - becomes more organized and contains many blood vessels.

Stroma - highly cellular connective tissue with fewer connective tissue fibers in which ovarian follicles are located.

Stromal Cells - spindle-shaped cells.

Medulla - inner region of fibroelastic connective tissue with many large, tortuous blood vessels, lymph vessels and nerve fibers.

Does not contain ovarian follicles.