T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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The spleen is an encapsulated organ that filters blood and immunologically monitors blood.
Capsule - dense connective tissue enclosing the organ.
Trabeculae - connective tissue that extends inward from the capsule through which blood vessels enter the pulp.
White Pulp - composed of lymphatic tissue. It appears basophilic due to the large number of nuclei.
Splenic Nodules (#1, #2 and #3) - clusters of B lymphocytes located on central arterioles. They usually contain a germinal center of activated B lymphocytes.
Central Arterioles (#1 and #2) - branches of trabecular arteries coated by PALS and adjacent to nodules.
PALS (Periarteriolar Lymphatic Sheath; #1 and #2) - cylindrical mass of mature T lymphocytes that surrounds central arterioles.
Marginal Zone - region between white and red pulp where macrophages, dendritic cells, and lymphocytes interact.
Red Pulp - filters and degrades red blood cells (RBCs). It appears eosinophilic due to the large number of RBCs.