T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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The corpus luteum of the ovary develops from the collapsed follicle after ovulation under the influence of luteinizing hormone (LH) from the pituitary.
Granulosa Lutein Cells - centrally located cells derived from granulosa cells. They form the majority of the corpus luteum.
Large cells (~30 µm diameter) with eosinophilic cytoplasm.
Secrete progesterone and convert androgens formed by theca lutein cells into estrogen.
Theca Lutein Cells - more peripherally located cells derived from theca interna cells.
Smaller cells (~15 µm diameter) more deeply stained than granulosa lutein cells.
Secrete androgens, progesterone and some estrogen.
Central Cavity - the blood and fibrin-containing clot has almost completely digested by macrophages at its periphery.
Atretic Follicles (#1 and #2) - follicles that fail to reach maturity and ovulation degrade by atresia. The disintegration of the granulosa stratum by apoptosis is an early event.
Medulla - inner region of fibroelastic connective tissue with many large, tortuous blood vessels, lymph vessels and nerve fibers.