T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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Ultrastructure of a fenestrated capillary showing a single layer of endothelial cells that contain pores (or fenestrations) spanned by a diaphragm (TEM). Longitudinal section of a capillary underneath the absorptive cells (or enterocytes) that line the small intestine.
Endothelium - one layer of simple squamous epithelial cells
Endothelial cell nuclei are not included in this section
(Tight or Occluding Junctions - abundant at overlapping folds between endothelial cells
Fenestrations (#1 and #2) - small circular pores (60-80 nm in diameter) that perforate thinner regions of endothelial cells
Spanned by a thin diaphragm that allows passage of small molecules and proteins
Transcytosis - small pinocytotic vesicles (60-80 nm in diameter) transport large molecules in both directions across endothelial cells
Basal Lamina (purple) - separates the capillary from the surrounding connective tissue