T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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Gondotrophs are cells in the anterior pituitary that produce the gonadotrophins, including follicle-stimulating hormone (FSH) or luteinizing hormone (LH).
Removal of the target gland by castration, gonadotropin cells become enlarged and contain hypertrophied rough endoplasmic reticulum. The cell is attempting to produce more gonadotropin to stimulate the gonads to secrete steriod hormones. Since the gonads were removed by castration, the production of sex steroids is impossible and the cell thereby is unable to shut off production of gonadotrophin hormones.