MH 020b Pig Snout Fetal

MICROSCOPE SLIDE

SLIDE NAME

MH 020b Pig Snout Fetal

TISSUE

Pig Snout Fetal

STAIN

Hematoxylin & Eosin

IMAGE SIZE

34,920 x 15,866 pixels
2.1 GB

FILE SIZE

145 MB

MAGNIFICATION

40x

PIXEL SIZE

0.3171 µm

SOURCE

Medical Histology Collection

CONTACT

Questions or comments should be sent to
tcbrelje@gmail.com

This web site is owned and operated by:

T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Version 4.2

© 2005-2019.
T. Clark Brelje and Robert L. Sorenson.
All rights reserved.

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MH 020b Pig Snout Fetal

Chondrogenesis

Developing cartilage occurs as two large, oval structures near the midline of this specimen. Cartilage development begins with the aggregation of mesenchymal cells that differentiate into chondroblasts. With the initiation of matrix production, the cells become surrounded by matrix and are called chondrocytes.

Cartilage growth continues by two processes:

Appositional Growth - forms new cartilage on the surface of existing cartilage. The perichondrium is a layer of dense irregular connective tissue that surrounds cartilage. It is divided into two layers:

Outer Fibrous Layer - contains fibroblasts that produce the type I collagen on the outer surface of the perichondrium.
Inner Chondrogenic Layer - contains fibroblast-like cells that differentiate into chondroblasts, initiate matrix production (type II collagen), and become immature chondrocytes. The new matrix increases cartilage mass.

Interstitial Growth - forms new cartilage within the existing cartilage. Chondrocytes divide and the daughter cells move apart from each other. This is only possible when the surrounding matrix is distensible.

Unlike the basophilia of mature cartilage, developing cartilage is pale staining because sulfated glycosaminoglycans (GAGs) have not been added to the matrix.