MH 046 Bone Development

MICROSCOPE SLIDE

SLIDE NAME

MH 046 Bone Development

TISSUES

Skull Cap (Calverium)
Epiphysis from a Femur

STAIN

Hematoxylin & Eosin
Decalcified Bone

IMAGE SIZE

48,960 x 39,529 pixels
7.2 GB

FILE SIZE

283 MB

MAGNIFICATION

40x

PIXEL SIZE

0.3171 µm

SOURCE

Medical Histology Collection

CONTACT

Questions or comments should be sent to
tcbrelje@gmail.com

This web site is owned and operated by:

T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455

Version 4.2

© 2005-2019.
T. Clark Brelje and Robert L. Sorenson.
All rights reserved.

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MH 046 Bone Development

Intramembranous Bone Formation

Different stages of intramembranous bone formation are seen in the skull cap (calvarium) when moving from the center to the right.

Condensation - mesenchymal cells migrate and aggregate into areas where bone will form (a bone blastema).
Osteoprogenitor Cells - the condensation of mesenchymal cells initiates the differentiation of osteoprogenitor cells.
Osteoblasts - the synthesis of components of the bone matrix indicates the further differentiation of osteoprogenitor cells into osteoblasts. Their basophilic cytoplasm is from the synthesis of proteins in osteoid (mostly type I collagen).
Osteoid - unmineralized, organic portion (type I collagen and ground substance) of bone matrix. Narrow, light-pink region between osteoblasts and the bone spicule.
Osteocytes - osteoblasts trapped inside lacunae of the bone.
Bone spicules - composed of women immature (or primary) bone with mineralized osteoid that is more basophilic than unmineralized osteoid.
Trabeculae - form from bone spicules that fuse with each other to provide the general shape of a developing bone.
Haversian System - developing osteons (#1, #2 and #3) can be recognized by blood vessels at the center of an area surrounded by osteoblasts.