T. Clark Brelje, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
Robert L. Sorenson, Ph.D.
University of Minnesota
Department of Genetics, Cell Biology and Development
6-160 Jackson Hall
321 Church St SE
Minneapolis, MN 55455
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The classic liver lobule is the traditional way to describe the organization of the liver parenchyma.
Lobules - individual lobules are seen as lighter areas with darker edges at low magnification.
Lobule Structure - roughly hexagonal structure with a central vein at its center and six portal triads at its periphery. (However, the random direction of a section makes this classical description rarely seen in a single profile.)
Central Vein - large venule at the center of the lobule.
Hepatocytes - anastomosing plates, one cell thick, radiate outward from the central vein separated by sinusoidal capillaries and supported by reticular fibers. (In this specimen the hepatocytes contain much lipofuscin.)
